{"id":33441,"date":"2022-11-22T09:24:10","date_gmt":"2022-11-22T09:24:10","guid":{"rendered":"https:\/\/gyncentrum.pl\/diagnostyka-nieplodnosci\/immunologia-rozrodu\/"},"modified":"2024-02-19T07:32:13","modified_gmt":"2024-02-19T07:32:13","slug":"reproductive-immunology","status":"publish","type":"servies","link":"https:\/\/gyncentrum.pl\/en\/infertility-diagnosis\/reproductive-immunology\/","title":{"rendered":"Reproductive immunology"},"content":{"rendered":"\n<section id=\"simple-hero-block_da164e8704d6f79222adb1786a3cab67\" class=\"block-simple-hero  \">\n    <div class=\"container\">\n        <h1 class=\"title\">Reproductive immunology<\/h1>\n        <div class=\"circle style-element\"><\/div>\n        <img decoding=\"async\" class=\"cross style-element\" src=\"https:\/\/gyncentrum.pl\/wp-content\/themes\/gyn-centrum\/img\/orange-cross.svg\" width=\"21\" height=\"21\" alt=\"\" title=\"\">\n        <div class=\"square style-element\"><\/div>\n    <\/div>\n<\/section>\n\n\n\n            <div class=\"container breadcrumbs-container custom-breadcrumbs-wrapper\">\n                <span>\n                    <span>\n                        <a href=\"https:\/\/gyncentrum.pl\/en\/\" class=\"home-link\">Home<\/a>\n                        <img decoding=\"async\" src=\"https:\/\/gyncentrum.pl\/wp-content\/themes\/gyn-centrum\/img\/breadcrumbs-arrow.svg\" class=\"breadcrumbs-separator\" alt=\"\" title=\"\">\n                        <span>\n                                                                <a href=\"https:\/\/gyncentrum.pl\/en\/infertility-diagnosis\/\">Infertility diagnosis<\/a>\n                                    <img decoding=\"async\"\n                                        src=\"https:\/\/gyncentrum.pl\/wp-content\/themes\/gyn-centrum\/img\/breadcrumbs-arrow.svg\"\n                                        class=\"breadcrumbs-separator\">\n                                                                <span class=\"breadcrumb_last\"\n                                  aria-current=\"page\">Reproductive immunology<\/span>\n                        <\/span>\n                    <\/span>\n                <\/span>\n            <\/div>\n\n            \n\n\n<section id=\"breadcrumbs-block_1e0df1ddda8df39bb3a209b290960762\" class=\"block-breadcrumbs \">\n    \n            <div class=\"container breadcrumbs-container \">\n                <span>\n                    <span>\n                        <a href=\"https:\/\/gyncentrum.pl\/en\/\" class=\"home-link\">Home<\/a>\n                        <img decoding=\"async\" src=\"https:\/\/gyncentrum.pl\/wp-content\/themes\/gyn-centrum\/img\/breadcrumbs-arrow.svg\" class=\"breadcrumbs-separator\" alt=\"\" title=\"\">\n                        <span>\n                                                                <a href=\"https:\/\/gyncentrum.pl\/en\/infertility-diagnosis\/\">Infertility diagnosis<\/a>\n                                    <img decoding=\"async\"\n                                        src=\"https:\/\/gyncentrum.pl\/wp-content\/themes\/gyn-centrum\/img\/breadcrumbs-arrow.svg\"\n                                        class=\"breadcrumbs-separator\">\n                                                                <span class=\"breadcrumb_last\"\n                                  aria-current=\"page\">Reproductive immunology<\/span>\n                        <\/span>\n                    <\/span>\n                <\/span>\n            <\/div>\n\n            <\/section>\n\n\n\n<section id=\"content-block_a611c49bbe0a13b0f2867c4169ca063d\" class=\"block-content image-right   \">\n        <div class=\"container\">\n        <div class=\"text-part\">\n            <div class=\"subtitle-wrapper\">\n                <div class=\"icon-wrapper\">\n                    <img decoding=\"async\" width=\"42\" height=\"41\" src=\"https:\/\/gyncentrum.pl\/wp-content\/uploads\/2022\/10\/orange-sketchy-heart.svg\" class=\"subtitle-icon lazyload\" alt=\"\" title=\"\">\n                <\/div>\n                <span class=\"subtitle text--t3\"><\/span>\n\n            <\/div>\n            <h3 class=\"title\"><p>A functioning immune system means a better chance of pregnancy!<\/p>\n<\/h3>\n            <div class=\"text text--t1\"><p>One of the increasingly common causes of pregnancy problems is immunological disorders. It is estimated that they can account for 6 to 12% of infertility cases. The earlier an immune disorder is diagnosed and the sooner treatment is instituted, the better the chances of a coveted pregnancy. Diagnosis of immune infertility is therefore worth starting as soon as possible!<\/p>\n<p>Immune infertility treatment uses immunostimulation and immunomodulatory methods preceded by a detailed analysis of the immunological mechanisms of reproduction.<\/p>\n<\/div>\n                    <a class=\"fz-button  new-button-style new-color-style-orange-100 new-fill-style-full\" href=\"#pop-up-first-visit-infertility-newv1\">\n        \n        <span class=\"text-itself\">Make an appointment for a consultation<\/span>\n\n                <\/a>\n        \n        <\/div>\n                    <div class=\"image-part\">\n                <img decoding=\"async\" class=\"heart-dust\" src=\"https:\/\/gyncentrum.pl\/wp-content\/themes\/gyn-centrum\/img\/orange-sketchy-heart-empty.svg\" width=\"28\" height=\"50\" alt=\"\" title=\"\">\n                <img decoding=\"async\" class=\"heart-dust-crocked\" src=\"https:\/\/gyncentrum.pl\/wp-content\/themes\/gyn-centrum\/img\/orange-sketchy-crocked-heart.svg\" width=\"42\" height=\"37\" alt=\"\" title=\"\">\n                <div class=\"dust dust-1\"><\/div>\n                <div class=\"dust dust-2\"><\/div>\n                <div class=\"dust dust-3 orange\"><\/div>\n                <div class=\"dust dust-4\"><\/div>\n                <div class=\"dust dust-5\"><\/div>\n                <div class=\"dust dust-6 orange\"><\/div>\n                <img decoding=\"async\" width=\"769\" height=\"749\" src=\"https:\/\/gyncentrum.pl\/wp-content\/uploads\/2023\/03\/immunologia-rozrodu.png\" class=\"side-image lazyload\" alt=\"immunologia_rozrodu_gyncentrum\" srcset=\"https:\/\/gyncentrum.pl\/wp-content\/uploads\/2023\/03\/immunologia-rozrodu.png 769w, https:\/\/gyncentrum.pl\/wp-content\/uploads\/2023\/03\/immunologia-rozrodu-200x195.png 200w, https:\/\/gyncentrum.pl\/wp-content\/uploads\/2023\/03\/immunologia-rozrodu-480x468.png 480w\" sizes=\"(max-width: 769px) 100vw, 769px\" title=\"\">            <\/div>\n                <\/div>\n<\/section>\n\n\n\n<section id=\"conent-2-block_3eedda2f8f59e15708dc31685b64a32d\" class=\"block-conent-2  image-type-container-width  \">\n        <div class=\"container \">\n                <div class=\"columns-wrapper\">\n            <div class=\"single-column\">\n                            <h3 class=\"title\"><p>How do immune disorders affect fertility?<\/p>\n<\/h3>\n                            <span class=\"text text--t1\"><p>The immune system (immune system) protects our body from attack by pathogens and from harmful effects of other agents. Sometimes, however, it ceases to do its job and instead of being our protector, it turns against us. <strong>A malfunctioning immune system disrupts the entire body and can cause immune infertility.<\/strong> A woman&#8217;s body can then produce antibodies that will either attack her own egg cells or fight her partner&#8217;s sperm, thus preventing fertilization. The body of a man suffering from immune infertility, on the other hand, can produce antibodies that will destroy the genetic material of sperm, also thus leading to infertility.<\/p>\n<\/span>\n                            <\/div>\n                    <\/div>\n\n    <\/div>\n<\/section>\n\n\n\n<section id=\"cta-block_7746353d577eafb6c4cc1c4f3a9eaa9d\" class=\"block-cta  \">\n    <div class=\"container block-cta__inner\">\n\n        <div class=\"c-text\">\n\n                            <span class=\"c-text__line\">\n                    Take the first step!\n                    \n                <\/span>\n                                    <span class=\"c-text__line c-text__line--second\">\n                        Read on or schedule a consultation at Gyncenter!                    <\/span>\n                            \n        <\/div>\n\n        <img decoding=\"async\"\n            src=\"data:image\/svg+xml,%3Csvg xmlns='http:\/\/www.w3.org\/2000\/svg' viewBox='0 0 3 2'%3E%3C\/svg%3E\"\n            data-src=\"https:\/\/gyncentrum.pl\/wp-content\/themes\/gyn-centrum\/img\/decor-heart.svg\"\n            alt=\"\"\n            class=\"block-cta__heart-decor lazyload\"\n        >\n\n                            <a class=\"fz-button navy-90 front-phone big-font\" href=\"tel:+48600466592\">\n        <svg width=\"20\" height=\"32\" viewBox=\"0 0 20 32\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n    <path d=\"M16 2C16.5304 2 17.0391 2.21071 17.4142 2.58579C17.7893 2.96086 18 3.46957 18 4V28C18 28.5304 17.7893 29.0391 17.4142 29.4142C17.0391 29.7893 16.5304 30 16 30H4C3.46957 30 2.96086 29.7893 2.58579 29.4142C2.21071 29.0391 2 28.5304 2 28V4C2 3.46957 2.21071 2.96086 2.58579 2.58579C2.96086 2.21071 3.46957 2 4 2H16ZM4 0C2.93913 0 1.92172 0.421427 1.17157 1.17157C0.421427 1.92172 0 2.93913 0 4V28C0 29.0609 0.421427 30.0783 1.17157 30.8284C1.92172 31.5786 2.93913 32 4 32H16C17.0609 32 18.0783 31.5786 18.8284 30.8284C19.5786 30.0783 20 29.0609 20 28V4C20 2.93913 19.5786 1.92172 18.8284 1.17157C18.0783 0.421427 17.0609 0 16 0L4 0Z\" fill=\"#ADACD4\"\/>\n    <path d=\"M10 28C10.5304 28 11.0391 27.7893 11.4142 27.4142C11.7893 27.0391 12 26.5304 12 26C12 25.4696 11.7893 24.9609 11.4142 24.5858C11.0391 24.2107 10.5304 24 10 24C9.46957 24 8.96086 24.2107 8.58579 24.5858C8.21071 24.9609 8 25.4696 8 26C8 26.5304 8.21071 27.0391 8.58579 27.4142C8.96086 27.7893 9.46957 28 10 28Z\" fill=\"#ADACD4\"\/>\n<\/svg>\n\n        <span class=\"text-itself\">+48 600 466 592<\/span>\n\n                <\/a>\n                    <\/div>\n<\/section>\n\n\n\n<section id=\"conent-2-block_7948a2bbf349649166ac26005376711b\" class=\"block-conent-2  image-type-container-width  \">\n        <div class=\"container \">\n                <div class=\"columns-wrapper\">\n            <div class=\"single-column\">\n                            <h3 class=\"title\"><p>Pregnancy despite immune infertility<\/p>\n<\/h3>\n                            <span class=\"text text--t1\"><p><strong>Despite immune infertility, fertilization is possible.<\/strong> The immune system does not always prevent the sperm from fusing with the egg cell. However, the resulting embryo contains the genetic material of the mother and father, so in the uterus it can be taken as an intruder. In such a situation, the woman&#8217;s body begins to fight it off and a miscarriage occurs. Immune disorders can impair both the process of fertilization, implantation of the already fertilized fetal egg and lead to habitual miscarriages. Immune disorders are estimated to account for about 65%-70% of pregnancy loss in women with habitual miscarriages. Both autoimmune and alloimmune factors play their part.<\/p>\n<\/span>\n                            <\/div>\n                            <div class=\"single-column\">\n                                            <span class=\"text text--t1\"><p>Immune infertility is a disorder that occurs only during a lifetime. This means that a couple may not have had any problems getting pregnant for the first time, while difficulties may already arise with the second pregnancy.<\/p>\n<p><strong>Therefore, all couples who:<\/strong><br \/>\n&#8211; already have a diagnosis of infertility<br \/>\n&#8211; have experienced habitual miscarriages<br \/>\n&#8211; often face inflammatory conditions<strong>should visit the immunology clinic<\/strong><\/p>\n<\/span>\n                                        <\/div>\n                        <\/div>\n\n    <\/div>\n<\/section>\n\n\n\n<section id=\"cta-banner-block_0cf9136cf5d142141099426eff90a25b\"\n         class=\"block-cta-banner \">\n            <div class=\"background-wrapper\">\n            <img decoding=\"async\" width=\"2560\" height=\"1584\" src=\"https:\/\/gyncentrum.pl\/wp-content\/uploads\/2024\/02\/aerial-view-of-wawel-castle-in-krakow-poland-scaled.jpg\" class=\"desktop-image background lazyload\" alt=\"\" srcset=\"https:\/\/gyncentrum.pl\/wp-content\/uploads\/2024\/02\/aerial-view-of-wawel-castle-in-krakow-poland-scaled.jpg 2560w, https:\/\/gyncentrum.pl\/wp-content\/uploads\/2024\/02\/aerial-view-of-wawel-castle-in-krakow-poland-768x475.jpg 768w, https:\/\/gyncentrum.pl\/wp-content\/uploads\/2024\/02\/aerial-view-of-wawel-castle-in-krakow-poland-1920x1188.jpg 1920w, https:\/\/gyncentrum.pl\/wp-content\/uploads\/2024\/02\/aerial-view-of-wawel-castle-in-krakow-poland-200x124.jpg 200w, https:\/\/gyncentrum.pl\/wp-content\/uploads\/2024\/02\/aerial-view-of-wawel-castle-in-krakow-poland-1536x951.jpg 1536w, https:\/\/gyncentrum.pl\/wp-content\/uploads\/2024\/02\/aerial-view-of-wawel-castle-in-krakow-poland-2048x1267.jpg 2048w, https:\/\/gyncentrum.pl\/wp-content\/uploads\/2024\/02\/aerial-view-of-wawel-castle-in-krakow-poland-930x576.jpg 930w, https:\/\/gyncentrum.pl\/wp-content\/uploads\/2024\/02\/aerial-view-of-wawel-castle-in-krakow-poland-480x297.jpg 480w\" sizes=\"(max-width: 2560px) 100vw, 2560px\" title=\"\">            <img decoding=\"async\" width=\"2560\" height=\"1584\" src=\"https:\/\/gyncentrum.pl\/wp-content\/uploads\/2024\/02\/aerial-view-of-wawel-castle-in-krakow-poland-scaled.jpg\" class=\"mobile-image background lazyload\" alt=\"\" srcset=\"https:\/\/gyncentrum.pl\/wp-content\/uploads\/2024\/02\/aerial-view-of-wawel-castle-in-krakow-poland-scaled.jpg 2560w, https:\/\/gyncentrum.pl\/wp-content\/uploads\/2024\/02\/aerial-view-of-wawel-castle-in-krakow-poland-768x475.jpg 768w, https:\/\/gyncentrum.pl\/wp-content\/uploads\/2024\/02\/aerial-view-of-wawel-castle-in-krakow-poland-1920x1188.jpg 1920w, https:\/\/gyncentrum.pl\/wp-content\/uploads\/2024\/02\/aerial-view-of-wawel-castle-in-krakow-poland-200x124.jpg 200w, https:\/\/gyncentrum.pl\/wp-content\/uploads\/2024\/02\/aerial-view-of-wawel-castle-in-krakow-poland-1536x951.jpg 1536w, https:\/\/gyncentrum.pl\/wp-content\/uploads\/2024\/02\/aerial-view-of-wawel-castle-in-krakow-poland-2048x1267.jpg 2048w, https:\/\/gyncentrum.pl\/wp-content\/uploads\/2024\/02\/aerial-view-of-wawel-castle-in-krakow-poland-930x576.jpg 930w, https:\/\/gyncentrum.pl\/wp-content\/uploads\/2024\/02\/aerial-view-of-wawel-castle-in-krakow-poland-480x297.jpg 480w\" sizes=\"(max-width: 2560px) 100vw, 2560px\" title=\"\">        <\/div>\n            <div class=\"container\">\n                <div class=\"content-wrapper\">\n                            <span class=\"subtitle text--t3\">Let&#8217;s meet in Cracow!<\/span>\n                            <h3            class=\"title\">Visit our Cracow Clinic        <\/h3>\n                    <div class=\"text text--t1\"><p>You want to learn more about our clinic?<\/p>\n<p>Don&#8217;t wait and and combine visiting our clinic with sightseeing around the Cracow.<\/p>\n<p>Click here, and schedule an appointment.<\/p>\n<\/div>\n                    <div class=\"button-row\">\n                    <a class=\"fz-button  new-button-style new-color-style-orange-100 new-fill-style-full\" href=\"https:\/\/gyncentrum.pl\/en\/gyncentrum-clinics\/gyncentrum-cracow\/\">\n        \n        <span class=\"text-itself\">Find out more<\/span>\n\n                <\/a>\n                <\/div>\n    <\/div>\n\n    <\/div>\n<\/section>\n\n\n\n<section id=\"conent-2-block_2ae2cc9de362423a12d67fb773a8702b\" class=\"block-conent-2  image-type-container-width  \">\n        <div class=\"container \">\n                <div class=\"columns-wrapper\">\n            <div class=\"single-column\">\n                            <h3 class=\"title\"><p>Immune infertility diagnosis &#8211; what tests does it include?<\/p>\n<\/h3>\n                            <span class=\"text text--t1\"><p>Immune infertility is a rather complex problem. Many different disorders can interfere with the immune system and indirectly cause immune infertility. So there are quite a few tests that need to be performed.<\/p>\n<p><strong>The most important immunological tests performed at Gyncentrum Clinic are:<\/strong><\/p>\n<p>&nbsp;<\/p>\n<ul>\n<li><strong>Immunophenotype from peripheral blood<\/strong> &#8211; it determines the number and proportion of individual lymphocytes in the blood<\/li>\n<li><strong>Congenital hypercoagulability Gene F2, F5 (Factor V Leiden + 20210 G-A mutation of prothrombin gene met. PCR)<\/strong> &#8211; this is a test for genetic susceptibility to blood clots (congenital thrombophilia). It is a common cause of immune infertility and miscarriages.<\/li>\n<li><strong>MTHFR thermolabile variant (MTHFR 1298C polymorphological variant determination + MTHFR C 677T thermolabile variant determination)<\/strong> &#8211; this is a genetic test for mutations in the MTHFR gene. These can cause, among other things, hypercoagulability and impaired folic acid metabolism.<\/li>\n<li><strong>Hypercoagulability package (congenital hypercoagulability Gene F2, F5 (factor V Leiden + 20210 G-A prothrombin gene mutation met. PCR) + thermolabile MTHFR variant)<\/strong> &#8211; this package combines testing for congenital thrombophilia and MTHFR gene testing<\/li>\n<li><strong>Testing for the APA 1 polymorphism in the IGF 2 gene<\/strong> &#8211; this is a test for men only. The presence of this polyformism increases the risk of miscarriage.<\/li>\n<li><strong>Mutation in the CFTR gene (290 mutations) male infertility (PCR method)<\/strong> &#8211; these mutations contribute to the development of cystic fibrosis and male infertility.<\/li>\n<li><strong>Y-chromosome microdeletions<\/strong> &#8211; this is a genetic test to see if Y-chromosome deletions are the cause of impaired male semen quality.<\/li>\n<li><strong>Azoospermia (PCR method)<\/strong> &#8211; this test checks whether a man suffers from azoospermia, which is a lack of sperm in semen.<\/li>\n<li><strong>Mutation 20210 G-A of the prothrombin gene (met. PCR<\/strong>) &#8211; this is a genetic test for a gene that may contribute to hypercoagulability.<\/li>\n<li><strong>Factor V Leiden (met. PCR)<\/strong> &#8211; also a tool for diagnosing predisposition to thrombosis.<\/li>\n<li><strong>Cystic fibrosis 205 mutations (met. PCR)<\/strong> &#8211; this involves checking whether a patient has cystic fibrosis. It is a systemic disease that manifests itself mainly through chronic bronchopulmonary disease.<\/li>\n<li><strong>Lupus anticoagulant, anticardiolipin antibodies (IgG, IgM), antibodies to \u03b22 -glycoprotein I (IgG, IgM), antibodies to phosphatidylserine (IgG, IgM), antibodies to phosphatidylinositol (IgG, IgM), prothrombin antibodies (IgG, IgM)<\/strong> &#8211; these analyses are performed to detect antiphospholipid syndrome, which can lead to immune infertility and recurrent miscarriages.<\/li>\n<li><strong>The presence of blocking antibodies (allo MLR)<\/strong> &#8211; the absence or deficiency of these antibodies leads to the treatment of the embryo as an intruder. As a result, the immune system begins to fight it, and the pregnancy cannot develop.<\/li>\n<li><strong>Microcytotoxic test<\/strong> &#8211; this is a test to see if there are antibodies in a woman&#8217;s blood that fight her partner&#8217;s lymphocytes. A positive result of the analysis means that they are likely to start fighting the embryo as well.<\/li>\n<li><strong>KIR<\/strong> &#8211; this analyzes the activity of receptors found on the surface of immune cells in the uterus.<\/li>\n<li><strong>Molecular tissue typing (HLA C)<\/strong> &#8211; this checks the expression of HLA-C tissue compatibility antigens. Among other things, it determines whether an embryo is considered a potential danger in the uterus.<\/li>\n<li><strong>Homocysteine<\/strong> &#8211; this is performed to determine the risk of thrombotic diseases<\/li>\n<li><strong>ANA1, ANA2, ANA3<\/strong> &#8211; these three tests check whether ANA antibodies are present in the patient&#8217;s body. Their presence indicates an ongoing autoimmune process. In healthy individuals, the test will show nothing.<\/li>\n<li><strong>Antinuclear antibodies type of luminescence<\/strong> &#8211; the test analyzes the type of luminescence and titer of ANA antibodies. This allows better diagnosis and monitoring of autoimmune diseases.<\/li>\n<li><strong>Inhibin B<\/strong> &#8211; this is a protein hormone that has a huge impact on fertility in men and women. Determination of its concentration can therefore be very helpful in the diagnosis of immune infertility.<\/li>\n<li><strong>Karyotype (cytogenetic test from peripheral blood)<\/strong> &#8211; is a genetic test that checks the patient&#8217;s set of chromosomes for their number, structure or size. Chromosome abnormalities can affect the entire body, including the immune system. This can translate into immune infertility.<\/li>\n<\/ul>\n<\/span>\n                        <a class=\"fz-button  new-button-style new-color-style-orange-100 new-fill-style-full\" href=\"#pop-up-first-visit-infertility-newv1\">\n        \n        <span class=\"text-itself\">Make an appointment<\/span>\n\n                <\/a>\n                    <\/div>\n                    <\/div>\n\n    <\/div>\n<\/section>\n\n\n\n<section id=\"cta-banner-block_de4a5407e962317feca1236d165535e8\"\n         class=\"block-cta-banner \">\n        <div class=\"container\">\n                    <div class=\"background-wrapper\">\n                <img decoding=\"async\" width=\"1920\" height=\"1080\" src=\"https:\/\/gyncentrum.pl\/wp-content\/uploads\/2023\/03\/immunologia_rozrodu_gyncentrum.png\" class=\"desktop-image background lazyload\" alt=\"immunologia_rozrodu_baner_gyncentrum\" srcset=\"https:\/\/gyncentrum.pl\/wp-content\/uploads\/2023\/03\/immunologia_rozrodu_gyncentrum.png 1920w, https:\/\/gyncentrum.pl\/wp-content\/uploads\/2023\/03\/immunologia_rozrodu_gyncentrum-768x432.png 768w, https:\/\/gyncentrum.pl\/wp-content\/uploads\/2023\/03\/immunologia_rozrodu_gyncentrum-200x113.png 200w, https:\/\/gyncentrum.pl\/wp-content\/uploads\/2023\/03\/immunologia_rozrodu_gyncentrum-1536x864.png 1536w, https:\/\/gyncentrum.pl\/wp-content\/uploads\/2023\/03\/immunologia_rozrodu_gyncentrum-930x523.png 930w, https:\/\/gyncentrum.pl\/wp-content\/uploads\/2023\/03\/immunologia_rozrodu_gyncentrum-480x270.png 480w\" sizes=\"(max-width: 1920px) 100vw, 1920px\" title=\"\">                <img decoding=\"async\" width=\"1920\" height=\"1080\" src=\"https:\/\/gyncentrum.pl\/wp-content\/uploads\/2022\/11\/immunologia_rozrodu_gyncentrum.webp\" class=\"mobile-image background lazyload\" alt=\"immunologia_rozrodu_gyncentrum\" srcset=\"https:\/\/gyncentrum.pl\/wp-content\/uploads\/2022\/11\/immunologia_rozrodu_gyncentrum.webp 1920w, https:\/\/gyncentrum.pl\/wp-content\/uploads\/2022\/11\/immunologia_rozrodu_gyncentrum-768x432.webp 768w, https:\/\/gyncentrum.pl\/wp-content\/uploads\/2022\/11\/immunologia_rozrodu_gyncentrum-200x113.webp 200w, https:\/\/gyncentrum.pl\/wp-content\/uploads\/2022\/11\/immunologia_rozrodu_gyncentrum-1536x864.webp 1536w, https:\/\/gyncentrum.pl\/wp-content\/uploads\/2022\/11\/immunologia_rozrodu_gyncentrum-930x523.webp 930w, https:\/\/gyncentrum.pl\/wp-content\/uploads\/2022\/11\/immunologia_rozrodu_gyncentrum-480x270.webp 480w\" sizes=\"(max-width: 1920px) 100vw, 1920px\" title=\"\">            <\/div>\n                    <div class=\"content-wrapper\">\n                        <h3            class=\"title\">        <\/h3>\n                    <div class=\"text text--t1\"><h3>Interpretation of the results of the mentioned tests should be handled by an immunologist.<\/h3>\n<p>This is a doctor who specializes in disorders of the immune system. He will accurately diagnose our problem and choose the appropriate form of therapy. His help may prove invaluable.<\/p>\n<\/div>\n                    <div class=\"button-row\">\n                    <a class=\"fz-button  new-button-style new-color-style-orange-100 new-fill-style-full\" href=\"tel:+48600466592\">\n        \n        <span class=\"text-itself\">Make a call<\/span>\n\n                <\/a>\n                <\/div>\n    <\/div>\n\n    <\/div>\n<\/section>\n\n\n\n<section id=\"conent-2-block_9f5d24170a9767d3305572f579aef956\" class=\"block-conent-2  image-type-container-width  \">\n        <div class=\"container \">\n                <div class=\"columns-wrapper\">\n            <div class=\"single-column\">\n                            <h3 class=\"title\"><p>Immune infertility treatment<\/p>\n<\/h3>\n                            <span class=\"text text--t1\"><p>Once the diagnosis of immune infertility is completed, we can begin treatment. Most often, it consists of taking preparations that alter the activity of the immune system, which are administered in the form of intravenous infusions. Couples with immune infertility are also advised to use assisted reproductive methods. One of these is insemination. It involves the introduction of pre-prepared sperm into the uterine cavity. We can undergo insemination several times. However, if it does not bring the expected results, it is worth going a step further and using in vitro fertilization. Thanks to it, we may be able to welcome a beautiful baby boy into the world. During treatment, we recommend not to stop natural efforts to have a child. Many couples, despite immunological infertility, manage to get pregnant naturally.<\/p>\n<\/span>\n                            <\/div>\n                    <\/div>\n\n    <\/div>\n<\/section>\n\n\n\n<section id=\"accordion-block_08ad5a454ece3e5460668a9a565708bb\" class=\"block-accordion   color-style-ligth\">\n    <div class=\"container\">\n        <div class=\"titles-wrapper\">\n                            <span class=\"subtitle text--t3\">FAQ<\/span>\n                                            <h2 class=\"title\">Frequently asked questions about <b>reproductive immunology<\/b><\/h2>\n                        <\/div>\n        <div class=\"questions-wrapper\">\n                            <div class=\"question-wrapper\">\n                    <div class=\"top-row\">\n                        <span class=\"top-text text--t1\">What immunological tests to perform in infertility?<\/span>\n                        <img decoding=\"async\" src=\"https:\/\/gyncentrum.pl\/wp-content\/themes\/gyn-centrum\/img\/dropdown-arrow.svg\" class=\"open-arrow lazyload\" width=\"14\" height=\"8\" alt=\"\" title=\"\">\n                    <\/div>\n                    <div class=\"content-row\"><p>Immune infertility is quite a complex problem, the list of tests needed to diagnose it is quite long. <strong>At the Gyncentrum clinic, we perform the following immunological tests:<\/strong><\/p>\n<ul>\n<li>Immunophenotype from peripheral blood<\/li>\n<li>Congenital hypercoagulability Gene F2, F5 (factor V Leiden + mutation 20210 G-A of prothrombin gene met. PCR)<\/li>\n<li>MTHFR thermolabile variant (MTHFR 1298C polymorphologic variant determination + MTHFR C 677T thermolabile variant determination)<\/li>\n<li>Hypercoagulability package (congenital hypercoagulability Gene F2, F5 (factor V Leiden + 20210 G-A mutation of prothrombin gene met. PCR) + thermolabile variant MTHFR)<\/li>\n<li>APA 1 polymorphism test in IGF 2 gene<\/li>\n<li>Mutation in the CFTR gene (290 mutations) male infertility (PCR met.)<\/li>\n<li>Y chromosome microdeletions<\/li>\n<li>Azoospermia (met. PCR)<\/li>\n<li>20210 G-A mutation of the prothrombin gene (met. PCR)<\/li>\n<li>Factor V Leiden (met. PCR)<\/li>\n<li>Cystic fibrosis 205 mutation (met. PCR)<\/li>\n<li>Lupus anticoagulant<\/li>\n<li>Anti-cardiolipin antibodies (IgG, IgM)<\/li>\n<li>Antibodies to \u03b22 -glycoprotein I (IgG, IgM)<\/li>\n<li>Antiphosphatidylserine antibodies (IgG, IgM)<\/li>\n<li>Antibodies against phosphatidylinositol (IgG, IgM)<\/li>\n<li>Antibodies against prothrombin (IgG, IgM)<\/li>\n<li>Presence of blocking antibodies (allo MLR)<\/li>\n<li>Microcytotoxicity test<\/li>\n<li>KIR<\/li>\n<li>Molecular tissue typing (HLA C)<\/li>\n<li>Homocysteine<\/li>\n<li>ANA1<\/li>\n<li>ANA2<\/li>\n<li>ANA3<\/li>\n<li>Antinuclear antibodies luminescent type<\/li>\n<li>Inhibin B<\/li>\n<li>Karyotype (cytogenetic study from peripheral blood)<\/li>\n<\/ul>\n<\/div>\n                <\/div>\n                                <div class=\"question-wrapper\">\n                    <div class=\"top-row\">\n                        <span class=\"top-text text--t1\">What is immune infertility?<\/span>\n                        <img decoding=\"async\" src=\"https:\/\/gyncentrum.pl\/wp-content\/themes\/gyn-centrum\/img\/dropdown-arrow.svg\" class=\"open-arrow lazyload\" width=\"14\" height=\"8\" alt=\"\" title=\"\">\n                    <\/div>\n                    <div class=\"content-row\"><p>Immune infertility is a type of infertility caused by a malfunctioning immune system that attacks its own reproductive cells, those of its partner, or produces antibodies directed against the embryo. <strong>According to various estimates, infertility is the reason why 6 to 12% of couples have difficulty obtaining and maintaining a pregnancy.<\/strong><\/p>\n<\/div>\n                <\/div>\n                                <div class=\"question-wrapper\">\n                    <div class=\"top-row\">\n                        <span class=\"top-text text--t1\">How much do immunological tests cost? <\/span>\n                        <img decoding=\"async\" src=\"https:\/\/gyncentrum.pl\/wp-content\/themes\/gyn-centrum\/img\/dropdown-arrow.svg\" class=\"open-arrow lazyload\" width=\"14\" height=\"8\" alt=\"\" title=\"\">\n                    <\/div>\n                    <div class=\"content-row\"><p>The range of tests performed in the diagnosis of immunological infertility is very wide, and their price varies and ranges <strong>from tens to hundreds of zlotys per test<\/strong>.<\/p>\n<\/div>\n                <\/div>\n                                <div class=\"question-wrapper\">\n                    <div class=\"top-row\">\n                        <span class=\"top-text text--t1\">Where to check for immune infertility? <\/span>\n                        <img decoding=\"async\" src=\"https:\/\/gyncentrum.pl\/wp-content\/themes\/gyn-centrum\/img\/dropdown-arrow.svg\" class=\"open-arrow lazyload\" width=\"14\" height=\"8\" alt=\"\" title=\"\">\n                    <\/div>\n                    <div class=\"content-row\"><p>You can perform immunological tests <strong>in our Gyncentrum clinic in Cracow.<\/strong><\/p>\n<\/div>\n   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<\/section>\n","protected":false},"excerpt":{"rendered":"<p>One of the increasingly common causes of pregnancy problems is immunological disorders. It is estimated that they can account for 6 to 12% of infertility cases.<\/p>\n","protected":false},"featured_media":0,"parent":33173,"menu_order":650,"template":"","class_list":["post-33441","servies","type-servies","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/gyncentrum.pl\/en\/wp-json\/wp\/v2\/servies\/33441","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/gyncentrum.pl\/en\/wp-json\/wp\/v2\/servies"}],"about":[{"href":"https:\/\/gyncentrum.pl\/en\/wp-json\/wp\/v2\/types\/servies"}],"version-history":[{"count":6,"href":"https:\/\/gyncentrum.pl\/en\/wp-json\/wp\/v2\/servies\/33441\/revisions"}],"predecessor-version":[{"id":34874,"href":"https:\/\/gyncentrum.pl\/en\/wp-json\/wp\/v2\/servies\/33441\/revisions\/34874"}],"up":[{"embeddable":true,"href":"https:\/\/gyncentrum.pl\/en\/wp-json\/wp\/v2\/servies\/33173"}],"wp:attachment":[{"href":"https:\/\/gyncentrum.pl\/en\/wp-json\/wp\/v2\/media?parent=33441"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}