{"id":33710,"date":"2022-11-26T10:56:46","date_gmt":"2022-11-26T10:56:46","guid":{"rendered":"https:\/\/gyncentrum.pl\/testy-nieplodnosciowe\/fertigen-woman\/"},"modified":"2024-02-21T09:45:53","modified_gmt":"2024-02-21T09:45:53","slug":"fertigen-woman","status":"publish","type":"servies","link":"https:\/\/gyncentrum.pl\/en\/infertility-tests\/fertigen-woman\/","title":{"rendered":"Fertigen Woman"},"content":{"rendered":"\n<section id=\"simple-hero-block_adf9b9367006fcac7c7db8e9dda093b9\" class=\"block-simple-hero  \">\n    <div class=\"container\">\n        <h1 class=\"title\">Fertigen Woman<\/h1>\n        <div class=\"circle style-element\"><\/div>\n        <img decoding=\"async\" class=\"cross style-element\" src=\"https:\/\/gyncentrum.pl\/wp-content\/themes\/gyn-centrum\/img\/orange-cross.svg\" width=\"21\" height=\"21\" alt=\"\" title=\"\">\n        <div class=\"square style-element\"><\/div>\n    <\/div>\n<\/section>\n\n\n\n            <div class=\"container breadcrumbs-container custom-breadcrumbs-wrapper\">\n                <span>\n                    <span>\n                        <a href=\"https:\/\/gyncentrum.pl\/en\/\" class=\"home-link\">Home<\/a>\n                        <img decoding=\"async\" src=\"https:\/\/gyncentrum.pl\/wp-content\/themes\/gyn-centrum\/img\/breadcrumbs-arrow.svg\" class=\"breadcrumbs-separator\" alt=\"\" title=\"\">\n                        <span>\n                                                                <a href=\"https:\/\/gyncentrum.pl\/en\/infertility-tests\/\">Infertility tests<\/a>\n                                    <img decoding=\"async\"\n                                        src=\"https:\/\/gyncentrum.pl\/wp-content\/themes\/gyn-centrum\/img\/breadcrumbs-arrow.svg\"\n                                        class=\"breadcrumbs-separator\">\n                                                                <span class=\"breadcrumb_last\"\n                                  aria-current=\"page\">Fertigen Woman<\/span>\n                        <\/span>\n                    <\/span>\n                <\/span>\n            <\/div>\n\n            \n\n\n<section id=\"content-block_fdde3b5151fc37e3aa3a1a571b05a4ff\" class=\"block-content image-right   \">\n        <div class=\"container\">\n        <div class=\"text-part\">\n            <div class=\"subtitle-wrapper\">\n                <div class=\"icon-wrapper\">\n                    <img decoding=\"async\" width=\"42\" height=\"41\" src=\"https:\/\/gyncentrum.pl\/wp-content\/uploads\/2022\/10\/orange-sketchy-heart.svg\" class=\"subtitle-icon lazyload\" alt=\"\" title=\"\">\n                <\/div>\n                <span class=\"subtitle text--t3\">GENETIC INFERTILITY TESTS <\/span>\n\n            <\/div>\n            <h3 class=\"title\"><p>Testing for genetic infertility in women.<\/p>\n<\/h3>\n            <div class=\"text text--t1\"><p>Fertigen Woman involves the analysis of about 150 genes in which the presence of pathogenic mutations contributes to infertility in women. <strong>Awareness of the presence of infertility with a genetic basis makes it possible to take appropriate measures to obtain a pregnancy and give birth to a healthy child.<\/strong><\/p>\n<p> At the<strong>Gyncentrum clinic, in addition to the Fertigen Woman test, we offer a panel of genetic tests for infertility aimed at men &#8211; Fertigen Men &#8211; which includes the analysis of about 80 gen <\/strong>es. <\/p>\n<\/div>\n                    <a class=\"fz-button  new-button-style new-color-style-orange-100 new-fill-style-full\" href=\"#pop-up-first-visit-infertility-newv1\">\n        \n        <span class=\"text-itself\">Make an appointment<\/span>\n\n                <\/a>\n        \n        <\/div>\n                    <div class=\"image-part\">\n                <img decoding=\"async\" class=\"heart-dust\" src=\"https:\/\/gyncentrum.pl\/wp-content\/themes\/gyn-centrum\/img\/orange-sketchy-heart-empty.svg\" 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src=\"https:\/\/gyncentrum.pl\/wp-content\/uploads\/2024\/02\/aerial-view-of-wawel-castle-in-krakow-poland-scaled.jpg\" class=\"desktop-image background lazyload\" alt=\"\" srcset=\"https:\/\/gyncentrum.pl\/wp-content\/uploads\/2024\/02\/aerial-view-of-wawel-castle-in-krakow-poland-scaled.jpg 2560w, https:\/\/gyncentrum.pl\/wp-content\/uploads\/2024\/02\/aerial-view-of-wawel-castle-in-krakow-poland-768x475.jpg 768w, https:\/\/gyncentrum.pl\/wp-content\/uploads\/2024\/02\/aerial-view-of-wawel-castle-in-krakow-poland-1920x1188.jpg 1920w, https:\/\/gyncentrum.pl\/wp-content\/uploads\/2024\/02\/aerial-view-of-wawel-castle-in-krakow-poland-200x124.jpg 200w, https:\/\/gyncentrum.pl\/wp-content\/uploads\/2024\/02\/aerial-view-of-wawel-castle-in-krakow-poland-1536x951.jpg 1536w, https:\/\/gyncentrum.pl\/wp-content\/uploads\/2024\/02\/aerial-view-of-wawel-castle-in-krakow-poland-2048x1267.jpg 2048w, 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https:\/\/gyncentrum.pl\/wp-content\/uploads\/2024\/02\/aerial-view-of-wawel-castle-in-krakow-poland-200x124.jpg 200w, https:\/\/gyncentrum.pl\/wp-content\/uploads\/2024\/02\/aerial-view-of-wawel-castle-in-krakow-poland-1536x951.jpg 1536w, https:\/\/gyncentrum.pl\/wp-content\/uploads\/2024\/02\/aerial-view-of-wawel-castle-in-krakow-poland-2048x1267.jpg 2048w, https:\/\/gyncentrum.pl\/wp-content\/uploads\/2024\/02\/aerial-view-of-wawel-castle-in-krakow-poland-930x576.jpg 930w, https:\/\/gyncentrum.pl\/wp-content\/uploads\/2024\/02\/aerial-view-of-wawel-castle-in-krakow-poland-480x297.jpg 480w\" sizes=\"(max-width: 2560px) 100vw, 2560px\" title=\"\">        <\/div>\n            <div class=\"container\">\n                <div class=\"content-wrapper\">\n                            <span class=\"subtitle text--t3\">Let&#8217;s meet in Cracow!<\/span>\n                            <h3            class=\"title\">Visit our Cracow Clinic        <\/h3>\n                    <div class=\"text text--t1\"><p>You want to learn more about our clinic?<\/p>\n<p>Don&#8217;t wait and and combine visiting our clinic with sightseeing around the Cracow.<\/p>\n<p>Click here, and schedule an appointment.<\/p>\n<\/div>\n                    <div class=\"button-row\">\n                    <a class=\"fz-button  new-button-style new-color-style-orange-100 new-fill-style-full\" href=\"https:\/\/gyncentrum.pl\/en\/gyncentrum-clinics\/gyncentrum-cracow\/\">\n        \n        <span class=\"text-itself\">Find out more<\/span>\n\n                <\/a>\n                <\/div>\n    <\/div>\n\n    <\/div>\n<\/section>\n\n\n\n<section id=\"conent-2-block_0d25b79a4ab596e0b37be2e232f177af\" class=\"block-conent-2  image-type-container-width  \">\n        <div class=\"container \">\n                <div class=\"columns-wrapper\">\n            <div class=\"single-column\">\n                                <span class=\"subtitle text--t3\">Indications <\/span>\n                            <h2 class=\"title\"><p>Who is the Fertigen Woman infertility panel for?<\/p>\n<\/h2>\n                            <span class=\"text text--t1\"><p><strong>Get tested for genetic infertility factors if:<\/strong><\/p>\n<ul>\n<li>You and your partner have been trying unsuccessfully for a child for a long time<\/li>\n<li>You are struggling with a primary absence of menstruation<\/li>\n<li>You have experienced multiple miscarriages<\/li>\n<li>You have been diagnosed with premature cessation of ovarian function<\/li>\n<\/ul>\n<\/span>\n                        <a class=\"fz-button  new-button-style new-color-style-orange-100 new-fill-style-full\" href=\"#pop-up-first-visit-infertility-newv1\">\n        \n        <span class=\"text-itself\">Learn more<\/span>\n\n                <\/a>\n                    <\/div>\n                            <div class=\"single-column\">\n                                            <span class=\"text text--t1\"><h3 style=\"font-weight: normal;\">Why perform Fertigen Woman?<\/h3>\n<p><strong>Molecular testing makes it possible to detect the genetic cause of infertility. With this knowledge it is possible to:<\/strong><\/p>\n<ul>\n<li>Estimate the chances of a natural pregnancy and its delivery<\/li>\n<li>Determine the direction of further actions aimed at obtaining offspring, such as the use of in vitro procedure, donation of reproductive cells, preimplantation diagnosis, etc.<\/li>\n<\/ul>\n<\/span>\n                                        <\/div>\n                        <\/div>\n\n    <\/div>\n<\/section>\n\n\n\n<section id=\"simplest-cta-block_d6fafdad7d7d38d826f13e6d18b75e91\" class=\"block-simplest-cta  color-style-dark \">\n    <div class=\"container\">\n        <div class=\"inner-wrapper\">\n                            <div class=\"icon-wrapper\">\n                    <img decoding=\"async\" width=\"42\" height=\"41\" src=\"https:\/\/gyncentrum.pl\/wp-content\/uploads\/2022\/10\/orange-sketchy-heart.svg\" class=\"icon lazyload\" alt=\"\" title=\"\">\n                <\/div>\n                                <h3 class=\"title\"><p><strong>Get a chance to become a mom!<\/strong><br \/>\nGet your genes tested and see if your infertility is genetic.<\/p>\n<\/h3>\n                                <div class=\"text\"><\/div>\n                            <div class=\"contact-wrapper\">\n                                    <a class=\"phone-link\" href=\"tel:600466592\">\n                        <img decoding=\"async\" src=\"https:\/\/gyncentrum.pl\/wp-content\/themes\/gyn-centrum\/img\/phone-icon.svg\" alt=\"phone\" height=\"32\" width=\"33\" title=\"\">\n                        <span class=\"number\">600 466 592<\/span>\n                    <\/a>\n                                                        <a class=\"email-address\" href=\"mailto:office@gyncentrum.pl \">\n                        <img decoding=\"async\" src=\"https:\/\/gyncentrum.pl\/wp-content\/themes\/gyn-centrum\/img\/mail-box.svg\" alt=\"phone\" height=\"22\" width=\"32\" title=\"\">\n                        <span class=\"address\">office@gyncentrum.pl <\/span>\n                    <\/a>\n                                <\/div>\n        <\/div>\n\n    <\/div>\n<\/section>\n\n\n\n<section id=\"conent-2-block_8e7db2e004d1cd9ca376abd73459ef6c\" class=\"block-conent-2  image-type-container-width  \">\n        <div class=\"container \">\n                <div class=\"columns-wrapper\">\n            <div class=\"single-column\">\n                                <span class=\"subtitle text--t3\">ABOUT THE STUDY <\/span>\n                            <h3 class=\"title\"><p>What genes do we test in the Fertigen Woman panel?<\/p>\n<\/h3>\n                            <span class=\"text text--t1\"><p><strong>The FertiGEN woman infertility panel includes analysis of the presence of mutations in the following genes:<\/strong><\/p>\n<p><em><strong>AIRE<\/strong>:<\/em> the gene contains the instruction to build a protein that functions as an &#8220;immune regulator.&#8221; This protein plays a special role in the thymus, a key organ of the immune system. The <em>AIRE<\/em> gene is crucial for the proper functioning of the ovaries, and its damage can cause premature ovarian expiration (premature ovarian expiration syndrome, POF) [1].<\/p>\n<p>DCAF17: mutation in this gene can lead to hypergonadotropic hypogonadism[2], a dysfunction of the gonads involving their structural damage, and consequently infertility. The presence of the mutation can also manifest as alopecia areata, diabetes and intellectual disability. These symptoms may be closely related to Woodhouse-Sakati syndrome, for the development of which this mutation is responsible.<\/p>\n<p>FIGLA: this gene encodes a protein that is an essential helix-loop-helix transcription factor regulating follicle maturation responsible for normal gonadal function. Mutation of this gene is associated with premature extinction of ovarian function, POI\/POF.<\/p>\n<p><em><strong>SOX8<\/strong><\/em>: the gene encodes a protein that is a transcription factor of the <em>SRY<\/em> gene. The <em>SRY <\/em>gene, in turn, is responsible for sex determination in humans and initiates testicular development. Mutations occurring in it in most cases lead to the reversal of the sex of XY individuals into female individuals, i.e. to the occurrence of Swyer syndrome [4]. <em>SOX8<\/em> mutation is also associated with primary ovarian insufficiency (POI), manifested by primary or secondary amenorrhea, infrequent menstruation, high FSH and LH levels, and estrogen deficiency, among others [5].<\/p>\n<\/span>\n                            <\/div>\n                            <div class=\"single-column\">\n                                            <span class=\"text text--t1\"><p><em><strong>SPRY4:<\/strong><\/em> mutation of this gene is associated with hypogonadotropic hypogonadism and Kallmann syndrome [6] being the cause of delayed puberty. Hypogonadotropic hypogonadism occurring in Kallmann syndrome is the result of GnRH deficiency. In women, this syndrome occurs much less frequently than in men [7] and manifests itself, among other things, in primary amenorrhea, absence of pubic hair and underdevelopment of the mammary glands.<\/p>\n<p>WNT4<em><strong>:<\/strong><\/em> is another gene responsible for female sex determination. Its damage leads to an increase in the synthesis of androgens (male sex hormones) and consequent masculinization. As a result of damage to the gene, the M\u00fcller ducts, the ducts from which the female sex organs develop, also fail to develop [4].<\/p>\n<p>And also in such genes as: <strong><em>AARS2, AMH, AMHR2, ANOS1, ANXA5, AR, ATG7, ATG9A, ATM, AXL, BLM, BMP15, BRCA2, BTG4, BUB1B, C11orf80, CCDC141, CCDC39, CHD7, CLPP, CPEB1, CYP17A1, CYP21A2, DAZL, DDX11, DIAPH2, DUSP6, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF4ENIF1, EMX2, ERAL1, ERCC2, ERCC3, ERCC4, ERCC6, ESR1, ESR2, F2, F5, FANCA, FBXO43, FEZF1, FGF17, FGF8, FGFR1, FLRT3, FOXL2, FSHB, FSHR, GALT, GATA4, GDF9, GNRH1, GNRHR, H6PD, HARS2, HAX1, HFM1, HNF1B, HOXA13, HS6ST1, HSD11B1, HSD17B4, IL17RD, INHA, KHDC3L, KISS1, KISS1R, LARS2, LHB, LHCGR, LHX1, LHX8, LHX9, LMNA, MCM8, MCM9, MEI1, MKKS, MRPS22, MSH5, NANOS3, NBN, NLRP2, NLRP5, NLRP7, NOBOX, NR0B1, NR3C1, NR5A1, NSMF, NUP107, PADI6, PATL2, PAX2, PAX8, PGM1, PGRMC1, PMM2, PNPLA6, POF1B, POLG, POLR3H, POU5F1, PPARG, PRLR, PROK2, PROKR2, PROP1, PSMC3IP, RCBTB1, REC114, REC8, RNF216, SEMA3A, SGO2, SLC29A3, SMC1B, SOHLH1, SOHLH2, SOX10, SPIDR, STAG3, SYCE1, SYCP3, TAC3, TGFBR3, TLE6, TP63, TRIM37, TRIP13, TUBB8, TWNK, WDR11, WEE2, WNT7A, WNT9B, WRN, WT1, XPA, XPC, XRCC2, XRCC4, ZP1, ZP2, ZP3.<\/em> <\/strong>In total, about 150 genes in which the presence of mutations can be responsible for infertility in a woman.<\/p>\n<\/span>\n                                <a class=\"fz-button  new-button-style new-color-style-orange-100 new-fill-style-full\" href=\"#pop-up-first-visit-infertility-newv1\">\n        \n        <span class=\"text-itself\">Find out more<\/span>\n\n                <\/a>\n                        <\/div>\n                        <\/div>\n\n    <\/div>\n<\/section>\n\n\n\n<section id=\"content-block_6730356f5148833b88514a460fc338a8\" class=\"block-content image-right  dark-background \">\n        <div class=\"container\">\n        <div class=\"text-part\">\n            <div class=\"subtitle-wrapper\">\n                <div class=\"icon-wrapper\">\n                    <img decoding=\"async\" width=\"42\" height=\"41\" src=\"https:\/\/gyncentrum.pl\/wp-content\/uploads\/2022\/10\/orange-sketchy-heart.svg\" class=\"subtitle-icon lazyload\" alt=\"\" title=\"\">\n                <\/div>\n                <span class=\"subtitle text--t3\">ABOUT THE METHOD <\/span>\n\n            <\/div>\n            <h2 class=\"title\"><p>Genetic testing for male infertility met. NGS<\/p>\n<\/h2>\n            <div class=\"text text--t1\"><p><strong>The test is carried out using the Next Generation Sequencing (NGS) method.<\/strong> The test material is deoxyribonucleic acid (DNA), isolated from the patient&#8217;s peripheral blood. The NGS method is now the &#8220;gold standard&#8221; for finding the cause of infertility in women. With its help, we read the entire coding sequence (exon) of the above-mentioned genes.<strong> Testing for genetically determined infertility using the NGS method is performed once, and the result is valid for life.<\/strong><\/p>\n<\/div>\n                    <a class=\"fz-button  new-button-style new-color-style-orange-100 new-fill-style-full\" href=\"#pop-up-first-visit-infertility-newv1\">\n        \n        <span class=\"text-itself\">Learn more<\/span>\n\n                <\/a>\n        \n        <\/div>\n                    <div class=\"image-part\">\n                <img decoding=\"async\" class=\"heart-dust\" src=\"https:\/\/gyncentrum.pl\/wp-content\/themes\/gyn-centrum\/img\/orange-sketchy-heart-empty.svg\" width=\"28\" height=\"50\" alt=\"\" title=\"\">\n                <img decoding=\"async\" class=\"heart-dust-crocked\" src=\"https:\/\/gyncentrum.pl\/wp-content\/themes\/gyn-centrum\/img\/orange-sketchy-crocked-heart.svg\" width=\"42\" height=\"37\" alt=\"\" title=\"\">\n                <div class=\"dust dust-1\"><\/div>\n                <div class=\"dust dust-2\"><\/div>\n                <div class=\"dust dust-3 orange\"><\/div>\n                <div class=\"dust dust-4\"><\/div>\n                <div class=\"dust dust-5\"><\/div>\n                <div class=\"dust dust-6 orange\"><\/div>\n                <img decoding=\"async\" width=\"6144\" height=\"4069\" src=\"https:\/\/gyncentrum.pl\/wp-content\/uploads\/2023\/04\/sekwencjonowanie-ngs.png\" class=\"side-image lazyload\" alt=\"sekwencjonowanie ngs\" srcset=\"https:\/\/gyncentrum.pl\/wp-content\/uploads\/2023\/04\/sekwencjonowanie-ngs.png 6144w, https:\/\/gyncentrum.pl\/wp-content\/uploads\/2023\/04\/sekwencjonowanie-ngs-768x509.png 768w, https:\/\/gyncentrum.pl\/wp-content\/uploads\/2023\/04\/sekwencjonowanie-ngs-1920x1272.png 1920w, https:\/\/gyncentrum.pl\/wp-content\/uploads\/2023\/04\/sekwencjonowanie-ngs-200x132.png 200w, https:\/\/gyncentrum.pl\/wp-content\/uploads\/2023\/04\/sekwencjonowanie-ngs-1536x1017.png 1536w, https:\/\/gyncentrum.pl\/wp-content\/uploads\/2023\/04\/sekwencjonowanie-ngs-2048x1356.png 2048w, https:\/\/gyncentrum.pl\/wp-content\/uploads\/2023\/04\/sekwencjonowanie-ngs-930x616.png 930w, https:\/\/gyncentrum.pl\/wp-content\/uploads\/2023\/04\/sekwencjonowanie-ngs-480x318.png 480w\" sizes=\"(max-width: 6144px) 100vw, 6144px\" title=\"\">            <\/div>\n                <\/div>\n<\/section>\n\n\n\n    <section id=\"spacer-block_bf849821e53d136ed23a5cf9086d7283\"\n             class=\"block-spacer  height-128px background-transparent\">\n    <\/section>\n\n\n\n<div class=\"container\">\n<h2 class=\"wp-block-heading\">What if the test reveals a genetic mutation? <\/h2>\n<\/div>\n\n\n    <section id=\"spacer-block_262dad15eb43e5b0217e0ecbe96f9d04\"\n             class=\"block-spacer  height-32px background-transparent\">\n    <\/section>\n\n\n\n<div class=\"container\">\n<p>Even small changes in genes can result in a lack of offspring. Genetic testing, on the other hand, makes it possible to estimate the chances of getting and keeping a pregnancy, as well as to determine the likelihood of possible defects or diseases in the child. With this knowledge, even at the stage of trying to get pregnant, the doctor can suggest effective solutions to achieve a pregnancy and give birth to a healthy child.<\/p>\n<\/div>\n\n<div class=\"container\">\n<p>Have you been trying with your partner for a pregnancy for more than a year or simply, want to see if you might have fertility problems in the future? Take the FertiGEN woman genetic testing panel. <strong>If the test reveals a genetic mutation in any of the genes tested, you will be able to consult with a Gyncentrum reproductive medicine specialist. He will discuss the result of the test with you, take a detailed medical history and indicate the most appropriate course of treatment.<\/strong><\/p>\n<\/div>\n\n\n<section id=\"conent-2-block_4891873c25d408f187e73ddf7af8ca1a\" class=\"block-conent-2  image-type-container-width  \">\n        <div class=\"container \">\n                <div class=\"columns-wrapper\">\n            <div class=\"single-column\">\n                            <h3 class=\"title\"><\/h3>\n                            <span class=\"text text--t1\"><p><em>Bibliography:<\/em><\/p>\n<p><em>[1] https:\/\/www.genecards.org\/cgi-bin\/carddisp.pl?gene=ADGRG2<\/em><br \/>\n<em>[2] https:\/\/www.orpha.net\/consor\/cgi-bin\/OC_Exp.php?Expert=244&amp;lng=PL<\/em><br \/>\n<em>[3] J. Czarny, Molecular basis of human sex determination and disorders of this process including the role of selected genes, https:\/\/ruj.uj.edu.en\/xmlui\/bitstream\/handle\/item\/272161\/czarny_molekular_podloze_determinacji_2020.pdf?sequence=1&amp;isAllowed=y<\/em><br \/>\n<em>[4] R. P. Piprek, Genetic basis of sex determination disorders and gonad development, Endocrinologia Polska, 2008, T. 59, no. 6, p. 507.<\/em><br \/>\n<em>[5] M. Rabijewski, Endocrinological causes of infertility in men, Fides et Ratio Scientific Quarterly, 2018, no. 3 (35), p. 178<\/em>.<\/p>\n<\/span>\n                            <\/div>\n                    <\/div>\n\n    <\/div>\n<\/section>\n\n\n\n    <section id=\"pop-up-block_25abc04d9eb8d02238c01bceb705dc66\"\n             class=\"block-pop-up  type-halfbyhalf color-style-light\">\n        <div id=\"first-visit-infertility-newv1\" class=\"pop-up closed\">\n            <div class=\"container\">\n                <div class=\"inner-wrapper\">\n                    <img decoding=\"async\" src=\"https:\/\/gyncentrum.pl\/wp-content\/themes\/gyn-centrum\/img\/close-cross.svg\" alt=\"\" class=\"close-cross lazyload\" width=\"12\" height=\"12\" title=\"\">\n\n                    <div class=\"content-wrapper\">\n\n                                                <h2                        class=\"title\"><p>Schedule a<strong> <span style=\"color: orange;\">\u00a0consultation <\/span><\/strong>with 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