Infertility tests

Even a small and completely inconspicuous change in genetic material can make it difficult to conceive a child. Statistically, in 15-20% of couples infertility is caused precisely by a genetic factor lying either on the side of the woman or on the side of the man. Genetic infertility can manifest itself in very different ways, such as reduced ovarian reserve in the female partner or low semen parameters in the partner. The influence of genetic factors on fertility can also be evidenced by recurrent miscarriages or unsuccessful attempts to conceive by IVF.

Genetic testing is therefore a key part of diagnosing the causes of partner infertility. By testing individual genes, we can not only find out the direct cause of the lack of offspring, but also increase the chance of getting pregnant and giving birth to a healthy child.

At theGyncentrum clinic, we have developed genetic testing panels dedicated to women and men. They include analysis of those genes whose mutation may contribute to infertility in both sexes. These tests are FertiGEN men and FertiGEN women.

The FertiGEN men’s test examines about 80 genes for mutations that may be responsible for infertility in men. Defects in any of them can impair the function of the testes or epididymides, interfere with their development, or affect the process of spermatogenesis (sperm formation) itself. Knowledge of the occurrence of infertility with a genetic basis allows you to take appropriate steps to increase the chance of obtaining a pregnancy and giving birth to a healthy child.

FertiGEN men infertility panel is designed to detect mutationsin, among others.in genes:

ADGRG2, CCDC40, DMRT1, SRY, GATA4, HS6ST1, LHCGR, AMH, AMHR2, ANOS1, APOA1, AR, AURKC, BLM, BNC2, CCDC141, CCDC39, CDC14A, CEP290, CFAP251, CFAP43, CFAP44, CFAP69, CFTR, CHD7, CYP11A1, CYP11B1, CYP17A1, CYP19A1, CYP21A2, DAZL, DCC, DNAAF11, DNAAF2, DNAAF4, DNAAF6, DNAH1, DPY19L2, FANCA, FANCM, FBXO43, FGF8, FGFR1, FSHB, FSHR, GNRH1, GNRHR, HSD17B3, HSD3B2, HSF2, IGF2, IL17RD, INSL3, KISS1, KLHL10, LHB, MAMLD1, NLRP3, NR0B1, NR5A1, PKD1, PLCZ1, PLXNA1, PMFBP1, PROK2, PROKR2, RSPO1, SEMA3A, SLC29A3. A total of 87 genes in which the presence of mutations may be responsible for male infertility.

The FertiGEN women’s test examines some 150 genes for mutations present in them that can lead to infertility in women. Defects in any of them can, for example, lead to primary ovarian failure, premature cessation of ovarian function, or delayed sexual maturation. Awareness that problems with getting pregnant have a genetic basis allows you to take appropriate measures towards the desired parenthood.

The FertiGEN woman infertility panel is designed to detect mutations in, among others. in genes:

AIRE, DCAF17, FIGLA, SOX8, SPRY4, WNT4, AARS2, AMH, AMHR2, ANOS1, ANXA5, AR, ATG7, ATG9A, ATM, AXL, BLM, BMP15, BRCA2, BTG4, BUB1B, C11orf80, CCDC141, CCDC39, CHD7, CLPP, CPEB1, CYP17A1, CYP21A2, DAZL, DDX11, DIAPH2, DUSP6, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF4ENIF1, EMX2, ERAL1, ERCC2, ERCC3, ERCC4, ERCC6, ESR1, ESR2, F2, F5, FANCA, FBXO43, FEZF1, FGF17, FGF8, FGFR1, FLRT3, FOXL2, FSHB, FSHR, GALT, GATA4, GDF9, GNRH1, GNRHR, H6PD. In total, there are about 150 genes whose mutation can cause infertility in women.